A semisynthetic borrelidin analogue BN-3b exerts potent antifungal activity against Candida albicans through ROS-mediated oxidative damage.
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ABSTRACT:
SUBMITTER: Su H
PROVIDER: S-EPMC7081223 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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A semisynthetic borrelidin analogue BN-3b exerts potent antifungal activity against Candida albicans through ROS-mediated oxidative damage.
Su Hao H Hu Caijuan C Cao Bixuan B Qu Xiaodan X Guan Peipei P Mu Yu Y Han Li L Huang Xueshi X
Scientific reports 20200319 1
In the process of investigating the antifungal structure-activity relationships (SAR) of borrelidin and discovering antifungal leads, a semisynthetic borrelidin analogue, BN-3b with antifungal activity against Candida albicans, was achieved. In this study, we found that oxidative damage induced by endogenous reactive oxygen species (ROS) plays an important role in the antifungal activity of BN-3b. Further investigation indicated that BN-3b stimulated ROS accumulation, increased malondialdehyde ( ...[more]
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