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Multi-Systemic Biological Risk and Cancer Mortality: The NHANES III Study.


ABSTRACT: Multi-systemic biological risk (MSBR), a proxy for allostatic load, is a composite index of biomarkers representing dysregulation due to responses to chronic stress. This study examined the association of an MSBR index with cancer mortality. The sample included n?=?13,628 adults aged 20-90 from the NHANES III Linked Mortality File (1988-1994). The MSBR index included autonomic (pulse rate, blood pressure), metabolic (HOMAir, triglycerides, waist circumference), and immune (white blood cell count, C-reactive protein) markers. We fit Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CI) of overall cancer mortality risk, according to quartiles (q) of the index. In multivariable models, compared to those in q1, q4 had a 64% increased risk for cancer mortality (HR?=?1.64, 95% CI:1.13-2.40). The immune domain drove the association (HR per unit?=?1.19, 95% CI:1.07-1.32). In stratified analyses, the HR for those with a BMI???25 was 1.12 per unit (95% CI:1.05-1.19) and those with a BMI?

SUBMITTER: Acheampong T 

PROVIDER: S-EPMC7081240 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Multi-Systemic Biological Risk and Cancer Mortality: The NHANES III Study.

Acheampong Teofilia T   Jiang Luohua L   Ziogas Argyrios A   Odegaard Andrew O AO  

Scientific reports 20200319 1


Multi-systemic biological risk (MSBR), a proxy for allostatic load, is a composite index of biomarkers representing dysregulation due to responses to chronic stress. This study examined the association of an MSBR index with cancer mortality. The sample included n = 13,628 adults aged 20-90 from the NHANES III Linked Mortality File (1988-1994). The MSBR index included autonomic (pulse rate, blood pressure), metabolic (HOMA<sub>ir</sub>, triglycerides, waist circumference), and immune (white blood  ...[more]

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