Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors.
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ABSTRACT:
SUBMITTER: Eksteen JJ
PROVIDER: S-EPMC7081261 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors.
Eksteen J Johannes JJ Ausbacher Dominik D Vasskog Terje T Rekdal Øystein Ø Svendsen John S M JSM
ACS omega 20200306 10
Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracellular delivery of a short antimicrobial peptide when conjugated to a histidine-rich peptide through a disulfide bond. The importance of exofacial thiols in the mode of action of these disulfide-linked ...[more]
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