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Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches.

ABSTRACT: Despite the tremendous importance of so-called ionizing radiations (X-rays, accelerated electrons and ions) in cancer treatment, most studies on their effects have focused on the ionization process itself, and neglect the excitation events the radiations can induce. Here, we show that the excited states of DNA exposed to accelerated electrons can be studied in the picosecond time domain using a recently developed cathodoluminescence system with high temporal resolution. Our study uses a table-top ultrafast, UV laser-triggered electron gun delivering picosecond electron bunches of keV energy. This scheme makes it possible to directly compare time-resolved cathodoluminescence with photoluminescence measurements. This comparison revealed qualitative differences, as well as quantitative similarities between excited states of DNA upon exposure to electrons or photons.

SUBMITTER: Renault JP

PROVIDER: S-EPMC7081262 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches.

Renault Jean Philippe JP Lucas Bruno B Gustavsson Thomas T Huetz Alain A Oksenhendler Thomas T Staicu-Casagrande Elena-Magdalena EM Géléoc Marie M

Scientific reports 20200319 1

Despite the tremendous importance of so-called ionizing radiations (X-rays, accelerated electrons and ions) in cancer treatment, most studies on their effects have focused on the ionization process itself, and neglect the excitation events the radiations can induce. Here, we show that the excited states of DNA exposed to accelerated electrons can be studied in the picosecond time domain using a recently developed cathodoluminescence system with high temporal resolution. Our study uses a table-to ...[more]

PMID: 32193504

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