Synthesis, Characterization, DNA Binding, Anticancer, and Molecular Docking Studies of Novel Imidazolium-Based Ionic Liquids with Fluorinated Phenylacetamide Tethers.

ABSTRACT: Newer imidazolium ionic liquid (IL) halides 4a-f appending variety of fluorinated phenylacetamide side chains were designed and synthesized through quaternization of 1-methyl and/or 1,2-dimethylimidazole with appropriate 2-chloro-N-(fluorinatedphenyl)acetamides. The resulting ILs were converted to their respective ionic liquid analogues carrying fluorinated counteranions (PF₆ ^-, BF₄ ^-, and/or CF₃COO^-) 5a-r. All newly synthesized ILs were fully characterized using several spectroscopic experiments such as ¹H, ¹³C, ¹¹B, ¹⁹F, ³¹P NMR, and mass analysis. The synthesized ionic liquids were investigated for their DNA binding and anticancer activities. The

SUBMITTER: Rezki N 

PROVIDER: S-EPMC7081306 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature