Ontology highlight
ABSTRACT:
SUBMITTER: Renard HF
PROVIDER: S-EPMC7081352 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Renard Henri-François HF Tyckaert François F Lo Giudice Cristina C Hirsch Thibault T Valades-Cruz Cesar Augusto CA Lemaigre Camille C Shafaq-Zadah Massiullah M Wunder Christian C Wattiez Ruddy R Johannes Ludger L van der Bruggen Pierre P Alsteens David D Morsomme Pierre P
Nature communications 20200319 1
While several clathrin-independent endocytic processes have been described so far, their biological relevance often remains elusive, especially in pathophysiological contexts such as cancer. In this study, we find that the tumor marker CD166/ALCAM (Activated Leukocyte Cell Adhesion Molecule) is a clathrin-independent cargo. We show that endophilin-A3-but neither A1 nor A2 isoforms-functionally associates with CD166-containing early endocytic carriers and physically interacts with the cargo. Our ...[more]