Aged mice show an increased mortality after anesthesia with a standard dose of ketamine/xylazine.
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ABSTRACT:
SUBMITTER: Schuetze S
PROVIDER: S-EPMC7081538 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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Aged mice show an increased mortality after anesthesia with a standard dose of ketamine/xylazine.
Schuetze Sandra S Manig Anja A Ribes Sandra S Nau Roland R
Laboratory animal research 20190724
Geriatric animal models are crucial for a better understanding and an improved therapy of age-related diseases. We observed a high mortality of aged mice after anesthesia with a standard dose of ketamine/xylazine, an anesthetic regimen frequently used in laboratory veterinary medicine. C57BL/6-N mice at the age of 2.14 ± 0.23 months (young mice) and 26.31 ± 2.15 months (aged mice) were anesthetized by intraperitoneal injection of 2 mg ketamine and 0.2 mg xylazine. 4 of 26 aged mice (15.4%) but n ...[more]
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