Ontology highlight
ABSTRACT:
SUBMITTER: Lee TK
PROVIDER: S-EPMC7081572 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lee Tae-Kyeong TK Park Young Eun YE Park Cheol Woo CW Kim Bora B Lee Jae-Chul JC Park Joon Ha JH Lee Hyang-Ah HA Won Moo-Ho MH Ahn Ji Hyeon JH
Laboratory animal research 20191029
P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult and aged mice by using immunohistochemistry. In addition, neuronal distribution and degeneration was examined by NeuN immunohistochemistry and fluoro-Jade B fluorescence staining. Strong p53 immunoreactivity was mainly expressed in pyramidal and granule cells of the hippocampus in young mice. p53 immunoreactiv ...[more]