Dataset Information

Human Plasmodium vivax diversity, population structure and evolutionary origin.

ABSTRACT: More than 200 million malaria clinical cases are reported each year due to Plasmodium vivax, the most widespread Plasmodium species in the world. This species has been neglected and understudied for a long time, due to its lower mortality in comparison with Plasmodium falciparum. A renewed interest has emerged in the past decade with the discovery of antimalarial drug resistance and of severe and even fatal human cases. Nonetheless, today there are still significant gaps in our understanding of the population genetics and evolutionary history of P. vivax, particularly because of a lack of genetic data from Africa. To address these gaps, we genotyped 14 microsatellite loci in 834 samples obtained from 28 locations in 20 countries from around the world. We discuss the worldwide population genetic structure and diversity and the evolutionary origin of P. vivax in the world and its introduction into the Americas. This study demonstrates the importance of conducting genome-wide analyses of P. vivax in order to unravel its complex evolutionary history.

SUBMITTER: Rougeron V

PROVIDER: S-EPMC7082039 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Human Plasmodium vivax diversity, population structure and evolutionary origin.

Rougeron Virginie V Elguero Eric E Arnathau Céline C Acuña Hidalgo Beatriz B Durand Patrick P Houze Sandrine S Berry Antoine A Zakeri Sedigheh S Haque Rashidul R Shafiul Alam Mohammad M Nosten François F Severini Carlo C Gebru Woldearegai Tamirat T Mordmüller Benjamin B Kremsner Peter Gottfried PG González-Cerón Lilia L Fontecha Gustavo G Gamboa Dionicia D Musset Lise L Legrand Eric E Noya Oscar O Pumpaibool Tepanata T Harnyuttanakorn Pingchai P Lekweiry Khadijetou Mint KM Mohamad Albsheer Musab M Mahdi Abdel Hamid Muzamil M Boukary Ali Ould Mohamed Salem AOMS Trape Jean-François JF Renaud François F Prugnolle Franck F

PLoS neglected tropical diseases 20200309 3

More than 200 million malaria clinical cases are reported each year due to Plasmodium vivax, the most widespread Plasmodium species in the world. This species has been neglected and understudied for a long time, due to its lower mortality in comparison with Plasmodium falciparum. A renewed interest has emerged in the past decade with the discovery of antimalarial drug resistance and of severe and even fatal human cases. Nonetheless, today there are still significant gaps in our understanding of ...[more]

PMID: 32150544

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Project description:In Central China the declining incidence of Plasmodium vivax has been interrupted by epidemic expansions and imported cases. The impact of these changes on the local parasite population, and concurrent risks of future resurgence, was assessed.Plasmodium vivax isolates collected from Anhui and Jiangsu provinces, Central China between 2007 and 2010 were genotyped using capillary electrophoresis at seven polymorphic short tandem repeat markers. Spatial and temporal analyses of within-host and population diversity, population structure, and relatedness were conducted on these isolates.Polyclonal infections were infrequent in the 94 isolates from Anhui (4%) and 25 from Jiangsu (12%), with a trend for increasing frequency from 2008 to 2010 (2 to 19%) when combined. Population diversity was high in both provinces and across the years tested (H(E)?=?0.8 - 0.85). Differentiation between Anhui and Jiangsu was modest (F'(ST)?=?0.1). Several clusters of isolates with identical multi-locus haplotypes were observed across both Anhui and Jiangsu. Linkage disequilibrium was strong in both populations and in each year tested (I(A)(S)?=?0.2 - 0.4), but declined two- to four-fold when identical haplotypes were accounted for, indicative of occasional epidemic transmission dynamics. None of five imported isolates shared identical haplotypes to any of the central Chinese isolates.The population genetic structure of P. vivax in Central China highlights unstable transmission, with limited barriers to gene flow between the central provinces. Despite low endemicity, population diversity remained high, but the reservoirs sustaining this diversity remain unclear. The challenge of imported cases and risks of resurgence emphasize the need for continued surveillance to detect early warning signals. Although parasite genotyping has potential to inform the management of outbreaks, further studies are required to identify suitable marker panels for resolving local from imported P. vivax isolates.

Dataset Information

Human Plasmodium vivax diversity, population structure and evolutionary origin.

Publications

Human Plasmodium vivax diversity, population structure and evolutionary origin.

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