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Survival advantage of chemoradiotherapy in anaplastic thyroid carcinoma: Propensity score matched analysis with multiple subgroups.

ABSTRACT: BACKGROUND:We compared overall survival (OS) between radiation therapy (RT) and chemoradiotherapy (CRT) in patients with anaplastic thyroid carcinoma (ATC) using a large database. METHODS:The National Cancer Data Base was queried for ATC patients diagnosed between 2004 and 2013 who received RT or CRT. Groups were balanced by propensity score matching (PSM) on nine relevant variables. OS was also examined in five paired subgroups given known patient heterogeneity. RESULTS:Of 858 total patients, 575 received CRT and 283 received RT. CRT was associated with decreased risk of death (hazard ratio [HR] 0.66, P

SUBMITTER: Tian S 

PROVIDER: S-EPMC7082181 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Survival advantage of chemoradiotherapy in anaplastic thyroid carcinoma: Propensity score matched analysis with multiple subgroups.

Tian Sibo S   Switchenko Jeffrey M JM   Fei Teng T   Press Robert H RH   Abugideiri Mustafa M   Saba Nabil F NF   Owonikoko Taofeek K TK   Chen Amy Y AY   Beitler Jonathan J JJ   Curran Walter J WJ   Gillespie Theresa W TW   Higgins Kristin A KA  

Head & neck 20191216 4

<h4>Background</h4>We compared overall survival (OS) between radiation therapy (RT) and chemoradiotherapy (CRT) in patients with anaplastic thyroid carcinoma (ATC) using a large database.<h4>Methods</h4>The National Cancer Data Base was queried for ATC patients diagnosed between 2004 and 2013 who received RT or CRT. Groups were balanced by propensity score matching (PSM) on nine relevant variables. OS was also examined in five paired subgroups given known patient heterogeneity.<h4>Results</h4>Of  ...[more]

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