Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC7082693 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wang Yange Y Fan Xiaobin X Lei Nanhang N He Xing X Wang Xiaoxi X Luo Xufeng X Zhang Dongmei D Pan Weiqing W
Frontiers in cellular and infection microbiology 20200313
Schistosomiasis remains a serious parasitic disease, which is characterized by granulomatous inflammation and hepatic fibrosis. MicroRNAs derived from parasites can regulate host genes and cell phenotype. Here, we showed that a miRNA derived from <i>S. japonicum</i> (Sja-miR-1) exists in the hepatic stellate cells (HSCs) of mice infected with the parasite and up-regulates the expression of collagens and α-SMA by targeting secreted frizzled-related protein 1 (SFRP1). A vector-mediated delivery of ...[more]