Ontology highlight
ABSTRACT:
SUBMITTER: Garibsingh RA
PROVIDER: S-EPMC7082830 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Garibsingh Rachel-Ann A RA Schlessinger Avner A
Trends in pharmacological sciences 20190910 10
There are over 420 human solute carrier (SLC) transporters from 65 families that are expressed ubiquitously in the body. The SLCs mediate the movement of ions, drugs, and metabolites across membranes and their dysfunction has been associated with a variety of diseases, such as diabetes, cancer, and central nervous system (CNS) disorders. Thus, SLCs are emerging as important targets for therapeutic intervention. Recent technological advances in experimental and computational biology allow better ...[more]