Assessing the effect of genetic markers on drug immunogenicity from a mechanistic model-based approach.

ABSTRACT:

Background

With the growth in use of biotherapic drugs in various medical fields, the occurrence of anti-drug antibodies represents nowadays a serious issue. This immune response against a drug can be due either to pre-existing antibodies or to the novel production of antibodies from B-cell clones by a fraction of the exposed subjects. Identifying genetic markers associated with the immunogenicity of biotherapeutic drugs may provide new opportunities for risk stratification before the introduction of the drug. However, real-world investigations should take into account that the population under study is a mixture of pre-immune, immune-reactive and immune-tolerant subjects.

Method

In this work, we propose a novel test for assessing the effect of genetic markers on drug immuno

SUBMITTER: Duhaze J 

PROVIDER: S-EPMC7082907 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature