Chloroquine Inhibits Stemness of Esophageal Squamous Cell Carcinoma Cells Through Targeting CXCR4-STAT3 Pathway.
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ABSTRACT:
SUBMITTER: Yue D
PROVIDER: S-EPMC7083143 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Chloroquine Inhibits Stemness of Esophageal Squamous Cell Carcinoma Cells Through Targeting CXCR4-STAT3 Pathway.
Yue Dongli D Zhang Daiqun D Shi Xiaojuan X Liu Shasha S Li Anqi A Wang Dong D Qin Guohui G Ping Yu Y Qiao Yamin Y Chen Xinfeng X Wang Feng F Chen Renyin R Zhao Song S Wang Lidong L Zhang Yi Y
Frontiers in oncology 20200313
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers worldwide. Recent studies have shown that cancer stem cells (CSCs) are present in ESCC, are thought to lead to aggressive tumor behavior and the prognosis. The CXC chemokine receptor 4 (CXCR4), is regarded as a putative CSCs marker in various malignancies. Here, we demonstrate that CXCR4 played a key role in ESCC progression and CXCR4 positive ESCC cells possessed stem-like properties. Furthermore, the anti-malarial a ...[more]
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