Dataset Information

Long-term diabetes risk among endometrial cancer survivors in a population-based cohort study.

ABSTRACT:

Objective

The majority of endometrial cancer patients are overweight or obese at cancer diagnosis. Obesity is a shared risk factor for both endometrial cancer and diabetes, but it is unknown whether endometrial cancer patients have increased diabetes risks. The aim of our study was to investigate diabetes risk among endometrial cancer patients.

Methods

Endometrial cancer patients diagnosed between 1997 and 2012 in Utah (n = 2,314) were identified. Women from the general population (n = 8,583) were matched to the cancer patients on birth year and birth state. Diabetes diagnoses were identified from electronic medical records and statewide healthcare facility databases. Cox proportional hazards models were used to estimate hazard ratios for diabetes after cancer diagnosis.

Results

Endometrial cancer survivors had a significantly higher risk of type II diabetes when compared to women from the general population in the first year after cancer diagnosis (HR = 5.22, 95% CI = 4.05, 6.71), >1-5 years after cancer diagnosis (HR = 1.67, 95% CI = 1.31, 2.12), and >5 years after cancer diagnosis (HR = 1.65, 95% CI = 1.29, 2.11). Endometrial cancer patients who were obese at cancer diagnosis had a three-fold increase in type II diabetes risk (HR = 2.99, 95%CI = 2.59, 3.45). Although endometrial cancer patients diagnosed at distant stage had a higher risk of diabetes, cancer treatment did not appear to contribute to any diabetes risks.

Conclusions

In conclusion, endometrial cancer survivors had a higher risk of diabetes than women in the general population. These results suggest that long term monitoring for diabetes is indicated for endometrial cancer survivors.

SUBMITTER: Kim S

PROVIDER: S-EPMC7083523 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Long-term diabetes risk among endometrial cancer survivors in a population-based cohort study.

Kim Seungmin S Park Jihye J Chen Yuji Y Rowe Kerry K Snyder John J Fraser Alison A Smith Ken K Deshmukh Vikrant G VG Newman Michael M Herget Kimberley K Porucznik Christina A CA Ose Dominik D Playdon Mary M Gaffney David D Hashibe Mia M

Gynecologic oncology 20191212 1

<h4>Objective</h4>The majority of endometrial cancer patients are overweight or obese at cancer diagnosis. Obesity is a shared risk factor for both endometrial cancer and diabetes, but it is unknown whether endometrial cancer patients have increased diabetes risks. The aim of our study was to investigate diabetes risk among endometrial cancer patients.<h4>Methods</h4>Endometrial cancer patients diagnosed between 1997 and 2012 in Utah (n = 2,314) were identified. Women from the general population ...[more]

PMID: 31839336

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Dataset Information

Long-term diabetes risk among endometrial cancer survivors in a population-based cohort study.

Objective

Methods

Results

Conclusions

Publications

Long-term diabetes risk among endometrial cancer survivors in a population-based cohort study.

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