Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC7083617 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Zhao Yueqi Y Fan Mingjie M Chen Yanni Y Liu Zhaoming Z Shao Changyu C Jin Biao B Wang Xiaoyu X Hui Lanlan L Wang Shuaifei S Liao Zhaoping Z Ling Daishun D Tang Ruikang R Wang Ben B
Science advances 20200320 12
Rhesus D (RhD) is one of the most important immunogenic antigens on red blood cells (RBCs). However, the supply of RhD-negative blood frequently faces critical shortages in clinical practice, and the positive-to-negative transition of the RhD antigen remains a great challenge. Here, we developed an alternative approach for sheltering the epitopes on RhD-positive RBCs using a surface-anchored framework, which is flexible but can achieve an optimal shield effect with minimal physicochemical influe ...[more]