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Invasive mucormycosis during treatment for acute lymphoblastic leukaemia-successful management of two life-threatening diseases.

ABSTRACT: A 5-year-old patient treated for acute lymphoblastic leukaemia (ALL) developed proven pulmonary invasive fungal disease (IFD) due to Actinomucor elegans. While completing ALL treatment according to AIEOP ALL protocol 2009 for further 15 months, antifungal treatment with liposomal amphotericin B and intermittent additional posaconazole was continued until immune reconstitution 7 months after the end of ALL treatment. Repeated imaging guided treatment decisions. Twenty-six and 19 months after the end of ALL treatment and antifungal treatment, respectively, the patient is still in the first complete remission and shows no signs of active invasive fungal disease (IFD).

SUBMITTER: Trobisch A

PROVIDER: S-EPMC7083803 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Invasive mucormycosis during treatment for acute lymphoblastic leukaemia-successful management of two life-threatening diseases.

Trobisch Andreas A Marterer R R Gorkiewicz G G Flaschberger S S Lackner H H Seidel M M Sperl D D Karastaneva A A Kohlmaier B B Egger M M Urban C C Benesch M M Strenger V V

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20190814 5

A 5-year-old patient treated for acute lymphoblastic leukaemia (ALL) developed proven pulmonary invasive fungal disease (IFD) due to Actinomucor elegans. While completing ALL treatment according to AIEOP ALL protocol 2009 for further 15 months, antifungal treatment with liposomal amphotericin B and intermittent additional posaconazole was continued until immune reconstitution 7 months after the end of ALL treatment. Repeated imaging guided treatment decisions. Twenty-six and 19 months after the ...[more]

PMID: 31410599

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