Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC7083825 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Xu Ying Y Zhao Zhe Z Tong Wenhua W Ding Yamei Y Liu Bin B Shi Yixin Y Wang Jichao J Sun Shenmei S Liu Min M Wang Yuhui Y Qi Qingsheng Q Xian Mo M Zhao Guang G
Nature communications 20200320 1
The ability to grow at moderate acidic conditions (pH 4.0-5.0) is important to Escherichia coli colonization of the host's intestine. Several regulatory systems are known to control acid resistance in E. coli, enabling the bacteria to survive under acidic conditions without growth. Here, we characterize an acid-tolerance response (ATR) system and its regulatory circuit, required for E. coli exponential growth at pH 4.2. A two-component system CpxRA directly senses acidification through protonati ...[more]