Ontology highlight
ABSTRACT:
SUBMITTER: Pak JS
PROVIDER: S-EPMC7083938 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Pak Joseph S JS DeLoughery Zachary J ZJ Wang Jing J Acharya Nischal N Park Yeonwoo Y Jaworski Alexander A Özkan Engin E
Nature communications 20200320 1
Axon pathfinding is critical for nervous system development, and it is orchestrated by molecular cues that activate receptors on the axonal growth cone. Robo family receptors bind Slit guidance cues to mediate axon repulsion. In mammals, the divergent family member Robo3 does not bind Slits, but instead signals axon repulsion from its own ligand, NELL2. Conversely, canonical Robos do not mediate NELL2 signaling. Here, we present the structures of NELL-Robo3 complexes, identifying a mode of ligan ...[more]