Ontology highlight
ABSTRACT:
SUBMITTER: Conicella AE
PROVIDER: S-EPMC7084079 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Conicella Alexander E AE Dignon Gregory L GL Zerze Gül H GH Schmidt Hermann Broder HB D'Ordine Alexandra M AM Kim Young C YC Rohatgi Rajat R Ayala Yuna M YM Mittal Jeetain J Fawzi Nicolas L NL
Proceedings of the National Academy of Sciences of the United States of America 20200304 11
Liquid-liquid phase separation (LLPS) is involved in the formation of membraneless organelles (MLOs) associated with RNA processing. The RNA-binding protein TDP-43 is present in several MLOs, undergoes LLPS, and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). While some ALS-associated mutations in TDP-43 disrupt self-interaction and function, here we show that designed single mutations can enhance TDP-43 assembly and function via modulating helical structure. Using mo ...[more]