Ontology highlight
ABSTRACT:
SUBMITTER: Slodkowicz G
PROVIDER: S-EPMC7084095 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Slodkowicz Greg G Goldman Nick N
Proceedings of the National Academy of Sciences of the United States of America 20200302 11
Understanding the molecular basis of adaptation to the environment is a central question in evolutionary biology, yet linking detected signatures of positive selection to molecular mechanisms remains challenging. Here we demonstrate that combining sequence-based phylogenetic methods with structural information assists in making such mechanistic interpretations on a genomic scale. Our integrative analysis shows that positively selected sites tend to colocalize on protein structures and that posit ...[more]