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The effects of evolutionary adaptations on spreading processes in complex networks.

ABSTRACT: A common theme among previously proposed models for network epidemics is the assumption that the propagating object (e.g., a pathogen [in the context of infectious disease propagation] or a piece of information [in the context of information propagation]) is transferred across network nodes without going through any modification or evolutionary adaptations. However, in real-life spreading processes, pathogens often evolve in response to changing environments and medical interventions, and information is often modified by individuals before being forwarded. In this article, we investigate the effects of evolutionary adaptations on spreading processes in complex networks with the aim of 1) revealing the role of evolutionary adaptations on the threshold, probability, and final size of epidemics and 2) exploring the interplay between the structural properties of the network and the evolutionary adaptations of the spreading process.

SUBMITTER: Eletreby R

PROVIDER: S-EPMC7084153 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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The effects of evolutionary adaptations on spreading processes in complex networks.

Eletreby Rashad R Zhuang Yong Y Carley Kathleen M KM Yağan Osman O Poor H Vincent HV

Proceedings of the National Academy of Sciences of the United States of America 20200302 11

A common theme among previously proposed models for network epidemics is the assumption that the propagating object (e.g., a pathogen [in the context of infectious disease propagation] or a piece of information [in the context of information propagation]) is transferred across network nodes without going through any modification or evolutionary adaptations. However, in real-life spreading processes, pathogens often evolve in response to changing environments and medical interventions, and inform ...[more]

PMID: 32123091

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Project description:We propose a theoretical framework for the study of spreading processes in structured metapopulations, with heterogeneous agents, subjected to different recurrent mobility patterns. We propose to represent the heterogeneity in the composition of the metapopulations as layers in a multiplex network, where nodes would correspond to geographical areas and layers account for the mobility patterns of agents of the same class. We analyze classical epidemic models within this framework and obtain an excellent agreement with extensive Monte Carlo simulations. This agreement allows us to derive analytical expressions of the epidemic threshold and to face the challenge of characterizing a real multiplex metapopulation, the city of Medellín in Colombia, where different recurrent mobility patterns are observed depending on the socioeconomic class of the agents. Our framework allows us to unveil the geographical location of those patches that trigger the epidemic state at the critical point. A careful exploration reveals that social mixing between classes and mobility crucially determines these critical patches and, more importantly, it can produce abrupt changes of the critical properties of the epidemic onset. Summary The spread of disease is strongly driven by how humans move and segregate across cities, regions, and countries. Understanding how epidemics arise from the interplay of these behaviors is crucial for implementing efficient containment and prevention policies. In this work, we propose a theoretical framework for the spread of pathogens that incorporates the real patterns of mobility, demographics, and human diversity observed in urban environments. Our framework represents various populations in a community as layers in a multiplex network, where nodes correspond to geographical areas and layers account for movement patterns. With this framework, we analyze a real urban system, the city of Medellin in Colombia, considering the interplay between six socioeconomic classes displaying disparate demographic segregation and mobility habits. Our framework can identify those neighborhoods and classes that trigger epidemic outbreaks. Remarkably, we observe that small changes to both mobility and social mixing among these subpopulations can trigger abrupt changes. As a consequence, containment strategies targeting a certain neighborhood can quickly change from efficient to useless. Finally, we provide a physical interpretation of the abrupt changes of those patches driving the unfolding of epidemics based on the effective number of contacts of agents. Our framework provides a reliable, time-saving platform for analyzing the spread of pathogens among various populations, allowing researchers to identify areas critical to the unfolding of diseases. With further improvements, our formalism could be extended to accommodate more sophisticated commuting patterns and epidemic models.

Dataset Information

The effects of evolutionary adaptations on spreading processes in complex networks.

Publications

The effects of evolutionary adaptations on spreading processes in complex networks.

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