Ontology highlight
ABSTRACT:
SUBMITTER: Liyanarachchi S
PROVIDER: S-EPMC7084156 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Liyanarachchi Sandya S Gudmundsson Julius J Ferkingstad Egil E He Huiling H Jonasson Jon G JG Tragante Vinicius V Asselbergs Folkert W FW Xu Li L Kiemeney Lambertus A LA Netea-Maier Romana T RT Mayordomo Jose I JI Plantinga Theo S TS Hjartarson Hannes H Hrafnkelsson Jon J Sturgis Erich M EM Brock Pamela P Nabhan Fadi F Thorleifsson Gudmar G Ringel Matthew D MD Stefansson Kari K de la Chapelle Albert A
Proceedings of the National Academy of Sciences of the United States of America 20200304 11
Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Here we assessed the combined genetic effects of these variants on PTC risk by using summarized GWAS results to build polygenic risk score (PRS) models in three PTC study groups from Ohio (1,544 patients and 1,593 controls), Iceland (723 patients and 129,556 contr ...[more]