MiR&moRe2: A Bioinformatics Tool to Characterize microRNAs and microRNA-Offset RNAs from Small RNA-Seq Data.
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ABSTRACT:
SUBMITTER: Gaffo E
PROVIDER: S-EPMC7084216 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
MiR&moRe2: A Bioinformatics Tool to Characterize microRNAs and microRNA-Offset RNAs from Small RNA-Seq Data.
Gaffo Enrico E Bortolomeazzi Michele M Bisognin Andrea A Di Battista Piero P Lovisa Federica F Mussolin Lara L Bortoluzzi Stefania S
International journal of molecular sciences 20200304 5
MicroRNA-offset RNAs (moRNAs) are microRNA-like small RNAs generated by microRNA precursors. To date, little is known about moRNAs and bioinformatics tools to inspect their expression are still missing. We developed miR&moRe2, the first bioinformatics method to consistently characterize microRNAs, moRNAs, and their isoforms from small RNA sequencing data. To illustrate miR&moRe2 discovery power, we applied it to several published datasets. MoRNAs identified by miR&moRe2 were in agreement with pr ...[more]
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