Dataset Information

Comprehensive Genome-Wide Approaches to Activity-Dependent Translational Control in Neurons.

ABSTRACT: Activity-dependent regulation of gene expression is critical in experience-mediated changes in the brain. Although less appreciated than transcriptional control, translational control is a crucial regulatory step of activity-mediated gene expression in physiological and pathological conditions. In the first part of this review, we overview evidence demonstrating the importance of translational controls under the context of synaptic plasticity as well as learning and memory. Then, molecular mechanisms underlying the translational control, including post-translational modifications of translation factors, mTOR signaling pathway, and local translation, are explored. We also summarize how activity-dependent translational regulation is associated with neurodevelopmental and psychiatric disorders, such as autism spectrum disorder and depression. In the second part, we highlight how recent application of high-throughput sequencing techniques has added insight into genome-wide studies on translational regulation of neuronal genes. Sequencing-based strategies to identify molecular signatures of the active neuronal population responding to a specific stimulus are discussed. Overall, this review aims to highlight the implication of translational control for neuronal gene regulation and functions of the brain and to suggest prospects provided by the leading-edge techniques to study yet-unappreciated translational regulation in the nervous system.

SUBMITTER: Choe HK

PROVIDER: S-EPMC7084349 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Comprehensive Genome-Wide Approaches to Activity-Dependent Translational Control in Neurons.

Choe Han Kyoung HK Cho Jun J

International journal of molecular sciences 20200226 5

Activity-dependent regulation of gene expression is critical in experience-mediated changes in the brain. Although less appreciated than transcriptional control, translational control is a crucial regulatory step of activity-mediated gene expression in physiological and pathological conditions. In the first part of this review, we overview evidence demonstrating the importance of translational controls under the context of synaptic plasticity as well as learning and memory. Then, molecular mecha ...[more]

PMID: 32111062

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Dataset Information

Comprehensive Genome-Wide Approaches to Activity-Dependent Translational Control in Neurons.

Publications

Comprehensive Genome-Wide Approaches to Activity-Dependent Translational Control in Neurons.

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