Ontology highlight
ABSTRACT:
SUBMITTER: Payne JL
PROVIDER: S-EPMC7084408 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Payne Jonathon L JL Song Chunhua C Ding Yali Y Dhanyamraju Pavan Kumar PK Bamme Yevgeniya Y Schramm Joseph W JW Desai Dhimant D Sharma Arati A Gowda Chandrika C Dovat Sinisa S
International journal of molecular sciences 20200303 5
Ikaros is a DNA-binding protein that regulates gene expression and functions as a tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL). The full cohort of Ikaros target genes have yet to be identified. Here, we demonstrate that Ikaros directly regulates expression of the small GTPase, Rab20. Using ChIP-seq and qChIP we assessed Ikaros binding and the epigenetic signature at the RAB20 promoter. Expression of Ikaros, CK2, and <i>RAB20</i> was determined by qRT-PCR. Overexpression of Ika ...[more]