Ontology highlight
ABSTRACT:
SUBMITTER: Chen T
PROVIDER: S-EPMC7084468 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Chen Tao T Ehnert Sabrina S Tendulkar Gauri G Zhu Sheng S Arnscheidt Christian C Aspera-Werz Romina H RH Nussler Andreas K AK
International journal of molecular sciences 20200310 5
Although several researchers have attested deleterious effects of smoking to the musculoskeletal system, the association between smoking and the onset of osteoarthritis (OA) remains unclear. Here, we investigate the effect of cigarette smoke extract (CSE) on primary human chondrocytes. The present study demonstrates that physiological concentrations of CSE (0.1%-10%) inhibit the viability, proliferation, and matrix formation of chondrocytes in a dose- and time-dependent manner. Significant amoun ...[more]