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Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata.


ABSTRACT: Acacia dealbata biomass, either from forest exploitation or from the management of invasive species, can be a strategic topic, namely as a source of high-value compounds. In this sense, the present study aimed at the detailed characterization of the lipophilic components of different morphological parts of A. dealbata and the evaluation of their cytotoxicity in cells representative of different mammals' tissues. The chemical composition of lipophilic extracts from A. dealbata bark, wood and leaves was evaluated using gas chromatography-mass spectrometry (GC-MS). Terpenic compounds (representing 50.2%-68.4% of the total bark and leaves extracts, respectively) and sterols (60.5% of the total wood extract) were the main components of these extracts. Other constituents, such as fatty acids, long-chain aliphatic alcohols, monoglycerides, and aromatic compounds were also detected in the studied extracts. All the extracts showed low or no cytotoxicity in the different cells tested, demonstrating their safety profile and highlighting their potential to be used in nutraceutical or pharmaceutical applications. This study is therefore an important contribution to the valorization of A. dealbata, demonstrating the potential of this species as a source of high value lipophilic compounds.

SUBMITTER: Oliveira CSD 

PROVIDER: S-EPMC7084485 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of <i>Acacia dealbata</i>.

Oliveira Cátia S D CSD   Moreira Patrícia P   Resende Judite J   Cruz Maria T MT   Pereira Cláudia M F CMF   Silva Artur M S AMS   Santos Sónia A O SAO   Silvestre Armando J D AJD  

International journal of molecular sciences 20200306 5


<i>Acacia dealbata</i> biomass, either from forest exploitation or from the management of invasive species, can be a strategic topic, namely as a source of high-value compounds. In this sense, the present study aimed at the detailed characterization of the lipophilic components of different morphological parts of <i>A. dealbata</i> and the evaluation of their cytotoxicity in cells representative of different mammals' tissues. The chemical composition of lipophilic extracts from <i>A. dealbata</i  ...[more]

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