Ontology highlight
ABSTRACT:
SUBMITTER: Bojcsuk D
PROVIDER: S-EPMC7084573 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Bojcsuk Dóra D Nagy Gergely G Bálint Bálint László BL
International journal of molecular sciences 20200227 5
Super-enhancers (SEs) are clusters of highly active enhancers, regulating cell type-specific and disease-related genes, including oncogenes. The individual regulatory regions within SEs might be simultaneously bound by different transcription factors (TFs) and co-regulators, which together establish a chromatin environment conducting to effective transcription. While cells with distinct TF profiles can have different functions, how different cells control overlapping genetic programs remains a q ...[more]