Overexpression of Malic Enzyme 2 Indicates Pathological and Clinical Significance in Oral Squamous Cell Carcinoma.
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ABSTRACT:
SUBMITTER: Zhou JJ
PROVIDER: S-EPMC7085265 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Overexpression of Malic Enzyme 2 Indicates Pathological and Clinical Significance in Oral Squamous Cell Carcinoma.
Zhou Jun-Jie JJ Xiao Yao Y Li Hao H Wu Cong-Cong CC Chen De-Run DR Chen Lei L Deng Wei-Wei WW Zhang Wen-Feng WF Sun Zhi-Jun ZJ
International journal of medical sciences 20200305 6
Our study investigated the expression of malic enzyme 2 (ME2) in human oral squamous cell carcinoma (OSCC) and associated pathological and clinical pattern. We demonstrated that human OSCC tissues expressed a high level of ME2, and the overexpression of ME2 is closely connected to a high pathological grade, lymphatic metastasis, large tumor size and human papillomavirus (HPV) (P <i><</i> 0.001). Similarly, high levels of ME2 expression in OSCC tissue were shown to be correlated with poor prognos ...[more]
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