Ontology highlight
ABSTRACT:
SUBMITTER: Kulminski AM
PROVIDER: S-EPMC7085286 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Alzheimer's & dementia (Amsterdam, Netherlands) 20200206 1
<h4>Introduction</h4>Apolipoprotein E (<i>APOE</i>) ε2 and ε4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively, are landmark contra and pro "risk" factors for Alzheimer's disease (AD).<h4>Methods</h4>We examined differences in linkage disequilibrium (LD) structures between (1) AD-affected and unaffected subjects and (2) older AD-unaffected and younger subjects in the 19q13.3 region harboring rs7412 and rs429358.<h4>Results</h4>AD is associated with sex-nonspecific heterogeneous ...[more]