Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K/Akt/mTOR.

ABSTRACT: Breast cancer is the cancer with the highest prevalence in women and is the number-one cause of cancer mortality worldwide. Cell transduction is a fundamental process in the development and progression of cancer. Modifications in various cell signalling pathways promote tumour cell proliferation, progression, and survival. The PI3K/Akt/mTOR pathway is an example of that, and it is involved in growth, proliferation, survival, motility, metabolism, and immune response regulation. Activation of this pathway is one of the main causes of cancer cell resistance to antitumour therapies. This makes PI3K/Akt/mTOR signalling a crucial object of study for understanding the development and progression of this disease. Thus, this pathway may have a role as a potential therapeutic target, as well as pro

SUBMITTER: Ortega MA 

PROVIDER: S-EPMC7085392 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature