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Systemic Lupus Erythematosus with Multiple Autoimmune Disease Presented with Extensive Peripheral Gangrene.

ABSTRACT: Systemic lupus erythematosus (SLE) is an autoimmune disease and can be associated with other autoimmune diseases. SLE usually presents with skin change and rarely presents with gangrene. SLE gangrene usually involves the digits of upper extremities. We report the first case of SLE associated with an extremely rare constellation of neuromyelitis Optica (NMO) and diabetes mellitus type 1, presented with a rare form of the SLE gangrene which involves bilateral lower extremities up to midlegs, a case that has not yet been reported in the literature. Although SLE gangrene may respond to immunosuppressants, it has a high risk of complications that can end up with amputations.

SUBMITTER: Alzughayyar TZ

PROVIDER: S-EPMC7085827 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Systemic Lupus Erythematosus with Multiple Autoimmune Disease Presented with Extensive Peripheral Gangrene.

Alzughayyar Tareq Z TZ Zalloum Jihad Samer JS Elqadi Mohammad N MN Abukhalaf Sadi A SA Abunejma Fawzy M FM Alkhanafsa Mohammed M Y MMY Haif Motasem H M MHM Alqarajeh Firas F Mesk Mo'min R MR Misk Rami A RA

Case reports in rheumatology 20200310

Systemic lupus erythematosus (SLE) is an autoimmune disease and can be associated with other autoimmune diseases. SLE usually presents with skin change and rarely presents with gangrene. SLE gangrene usually involves the digits of upper extremities. We report the first case of SLE associated with an extremely rare constellation of neuromyelitis Optica (NMO) and diabetes mellitus type 1, presented with a rare form of the SLE gangrene which involves bilateral lower extremities up to midlegs, a cas ...[more]

PMID: 32231842

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