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Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature.

ABSTRACT: Crizotinib is a first-line tyrosine kinase inhibitor used for the treatment of metastatic lung cancer. Crizotinib-induced hepatotoxicity is a rare event. We report a case of a 46-year-old female with a history of metastatic lung cancer who presented with acute liver failure after being on crizotinib for two months. The medication was discontinued, and she was treated with N-acetylcysteine for seven days. Her liver function tests returned to normal limits after 26 days after admission. The precise mechanism and risk factors of crizotinib-induced hepatotoxicity remain unknown. Physicians should be aware of the potentially lethal side effect caused by crizotinib.

SUBMITTER: Kreitman K

PROVIDER: S-EPMC7085870 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature.

Kreitman Kyle K Nair Satheesh P SP Kothadia Jiten P JP

Case reports in hepatology 20200310

Crizotinib is a first-line tyrosine kinase inhibitor used for the treatment of metastatic lung cancer. Crizotinib-induced hepatotoxicity is a rare event. We report a case of a 46-year-old female with a history of metastatic lung cancer who presented with acute liver failure after being on crizotinib for two months. The medication was discontinued, and she was treated with N-acetylcysteine for seven days. Her liver function tests returned to normal limits after 26 days after admission. The precis ...[more]

PMID: 32231818

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