Comparison of conventional and rapid-acting antidepressants in a rodent probabilistic reversal learning task.

ABSTRACT: Deficits in reward processing are a central feature of major depressive disorder with patients exhibiting decreased reward learning and altered feedback sensitivity in probabilistic reversal learning tasks. Methods to quantify probabilistic learning in both rodents and humans have been developed, providing translational paradigms for depression research. We have utilised a probabilistic reversal learning task to investigate potential differences between conventional and rapid-acting antidepressants on reward learning and feedback sensitivity. We trained 12 rats in a touchscreen probabilistic reversal learning task before investigating the effect of acute administration of citalopram, venlafaxine, reboxetine, ketamine or scopolamine. Data were also analysed using a Q-learning reinforcement

SUBMITTER: Wilkinson MP 

PROVIDER: S-EPMC7085917 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature