Primary age-related tauopathy in a Chinese cohort.

ABSTRACT: Primary age-related tauopathy (PART) is characterized by the presence of tau neurofibrillary tangles (NFTs) which are typically observed in Alzheimer's disease (AD) brains, with few or without ?-amyloid (A?) plaques. The diagnosis of PART can be categorized into "definite" or "possible" depending on the amount of A? plaques. Definite PART is diagnosed when NFTs are observed and the Braak stage is ?IV, with Thal A? Phase 0 (Crary et al., 2014). According to the neuropathological diagnostic criteria, we reported that PART was frequently observed in the Chinese population according to our findings from specimens in our brain bank, with 47% of brain bank subjects meeting the criteria for PART. There is no consensus on the nature of PART. It remains to be elucidated whether PART is an early form of AD or a novel tauopathy (Duyckaerts et al., 2015; Jellinger et al., 2015).

SUBMITTER: Wang X 

PROVIDER: S-EPMC7086008 | biostudies-literature | 2020 Mar.

REPOSITORIES: biostudies-literature