Ontology highlight
ABSTRACT:
SUBMITTER: Coles CH
PROVIDER: S-EPMC7086387 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Coles Charlotte H CH Mulvaney Rachel M RM Malla Sunir S Walker Andrew A Smith Kathrine J KJ Lloyd Angharad A Lowe Kate L KL McCully Michelle L ML Martinez Hague Ruth R Aleksic Milos M Harper Jane J Paston Samantha J SJ Donnellan Zoe Z Chester Fiona F Wiederhold Katrin K Robinson Ross A RA Knox Andrew A Stacey Andrea R AR Dukes Joseph J Baston Emma E Griffin Sue S Jakobsen Bent K BK Vuidepot Annelise A Harper Stephen S
Journal of immunology (Baltimore, Md. : 1950) 20200226 7
The molecular rules driving TCR cross-reactivity are poorly understood and, consequently, it is unclear the extent to which TCRs targeting the same Ag recognize the same off-target peptides. We determined TCR-peptide-HLA crystal structures and, using a single-chain peptide-HLA phage library, we generated peptide specificity profiles for three newly identified human TCRs specific for the cancer testis Ag NY-ESO-1<sub>157-165</sub>-HLA-A2. Two TCRs engaged the same central peptide feature, althoug ...[more]