Organoids as a Powerful Model for Respiratory Diseases.
Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC7086445 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Organoids as a Powerful Model for Respiratory Diseases.
Li Yu Y Wu Qi Q Sun Xin X Shen Jun J Chen Huaiyong H
Stem cells international 20200311
Insults to the alveoli usually lead to inefficient gas exchange or even respiratory failure, which is difficult to model in animal studies. Over the past decade, stem cell-derived self-organizing three-dimensional organoids have emerged as a new avenue to recapitulate respiratory diseases in a dish. Alveolar organoids have improved our understanding of the mechanisms underlying tissue homeostasis and pathological alterations in alveoli. From this perspective, we review the state-of-the-art techn ...[more]
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