Ontology highlight
ABSTRACT:
SUBMITTER: Do VT
PROVIDER: S-EPMC7087028 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Archives of virology 20200116 3
Porcine epidemic diarrhea virus (PEDV) targets the intestinal mucosa in pigs. To protect against PEDV invasion, a mucosal vaccine is utilized effectively. In this study, we generated a recombinant adenovirus vaccine encoding the heat-labile enterotoxin B (LTB) and the core neutralizing epitope (COE) of PEDV (rAd-LTB-COE). The fusion protein LTB-COE was successfully expressed by the recombinant adenovirus in HEK293 cells, and the immunogenicity of the vaccine candidate was assessed in BALB/c mice ...[more]