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New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017.


ABSTRACT: Four types of porcine epidemic diarrhea virus (PEDV) variants with a large deletion in the spike protein were detected, together with the original US PEDV, from pig fecal and oral fluid samples collected during 2016-2017 in the US. Two of the variants are similar to those identified in Japan: one contains a 194-aa deletion, the same as PEDV variant TTR-2/JPN/2014, while the other contains a 204-aa deletion, the same as PEDV variant JKa-292/CS1de204. Two new S1 NTD-del PEDV variants were found: one contains a 201-aa deletion located at residues 30-230 and the other contains a 202-aa deletion located at residues 24-225 of the S protein. This is the first report on coinfection of S1 NTD-del PEDV variants and the original US PEDV strain in US pigs, indicating that PEDV continues to evolve in pigs and might be responsible for disease pattern changes.

SUBMITTER: Su Y 

PROVIDER: S-EPMC7087112 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017.

Su Yunfang Y   Hou Yixuan Y   Prarat Melanie M   Zhang Yan Y   Wang Qiuhong Q  

Archives of virology 20180522 9


Four types of porcine epidemic diarrhea virus (PEDV) variants with a large deletion in the spike protein were detected, together with the original US PEDV, from pig fecal and oral fluid samples collected during 2016-2017 in the US. Two of the variants are similar to those identified in Japan: one contains a 194-aa deletion, the same as PEDV variant TTR-2/JPN/2014, while the other contains a 204-aa deletion, the same as PEDV variant JKa-292/CS1de204. Two new S1 NTD-del PEDV variants were found: o  ...[more]

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