Ontology highlight
ABSTRACT:
SUBMITTER: Ishag HZ
PROVIDER: S-EPMC7087312 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Archives of virology 20121007 2
Griffithsin (GRFT) is a broad-spectrum antiviral protein that is effective against several glycosylated viruses. Here, we have evaluated the in vitro and in vivo antiviral activities of GRFT against Japanese encephalitis virus (JEV) infection. In vitro experiments showed that treatment of JEV with GRFT before inoculation of BHK-21 cells inhibited infection in a dose-dependent manner, with 99 % inhibition at 100 μg/ml and a 50 % inhibitory concentration (IC(50)) of 265 ng/ml (20 nM). Binding assa ...[more]