Positive selection of the bat interferon alpha gene family.
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ABSTRACT:
SUBMITTER: He G
PROVIDER: S-EPMC7088374 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Positive selection of the bat interferon alpha gene family.
He Guimei G He Beibei B Racey Paul A PA Cui Jie J
Biochemical genetics 20100714 9-10
Type I interferons (IFNs) are produced by leukocytes in reaction to pathogenic infection and function as positive mediators in antiviral pathways. Among IFNs, IFN alpha (IFNA) has the largest number of family members and plays an important role against the invasion of pathogens. Bats are putative and proven vectors for numerous viruses; however, the evolution of the IFNA family in bats has not been addressed. Here, we construct a phylogeny of IFNA families, including one fruit bat (Dobsonia viri ...[more]
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