Unknown

Dataset Information

0

Lymphatic Function and Dysfunction in the Context of Sex Differences.


ABSTRACT: Endothelial cells are the building blocks of the blood vascular system and exhibit well-characterized sexually dimorphic phenotypes with regard to chromosomal and hormonal sex, imparting innate genetic and physiological differences between male and female vascular systems and cardiovascular disease. However, even though females are predominantly affected by disorders of lymphatic vascular function, we lack a comprehensive understanding of the effects of sex and sex hormones on lymphatic growth, function, and dysfunction. Here, we attempt to comprehensively evaluate the current understanding of sex as a biological variable influencing lymphatic biology. We first focus on elucidating innate and fundamental differences between the sexes in lymphatic function and development. Next, we delve into lymphatic disease and explore the potential underpinnings toward bias prevalence in the female population. Lastly, we incorporate more broadly the role of the lymphatic system in sex-biased diseases such as cancer, cardiovascular disease, reproductive disorders, and autoimmune diseases to explore whether and how sex differences may influence lymphatic function in the context of these pathologies.

SUBMITTER: Trincot CE 

PROVIDER: S-EPMC7089000 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Lymphatic Function and Dysfunction in the Context of Sex Differences.

Trincot Claire E CE   Caron Kathleen M KM  

ACS pharmacology & translational science 20190909 5


Endothelial cells are the building blocks of the blood vascular system and exhibit well-characterized sexually dimorphic phenotypes with regard to chromosomal and hormonal sex, imparting innate genetic and physiological differences between male and female vascular systems and cardiovascular disease. However, even though females are predominantly affected by disorders of lymphatic vascular function, we lack a comprehensive understanding of the effects of sex and sex hormones on lymphatic growth,  ...[more]

Similar Datasets

| S-EPMC5555215 | biostudies-other
| S-EPMC10956361 | biostudies-literature
| S-EPMC9253085 | biostudies-literature
2016-08-11 | E-GEOD-85415 | biostudies-arrayexpress
2022-01-31 | GSE194151 | GEO
| S-EPMC3107935 | biostudies-literature
| S-EPMC5503813 | biostudies-literature
2016-08-11 | GSE85415 | GEO
| S-EPMC6537500 | biostudies-literature
| S-EPMC6002844 | biostudies-literature