Ontology highlight
ABSTRACT:
SUBMITTER: Shulyatnikova T
PROVIDER: S-EPMC7089215 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Shulyatnikova Tatyana T Verkhratsky Alexei A
Neurochemical research 20190218 1
Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly characterised. Brain pathology in SAE, which is manifested by impaired perception, consciousness and cognition, results from multifactorial events, including high levels of systemic cytokines, microbial components and endotoxins, which all damage the brain barriers, instigate neuroinflammation and cause homeostatic failure. Astrocytes, being the principal homeostatic cells of the central nervous system contribute t ...[more]