Metabolic lesion-deficit mapping of human cognition.
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ABSTRACT:
SUBMITTER: Jha A
PROVIDER: S-EPMC7089650 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Metabolic lesion-deficit mapping of human cognition.
Jha Ashwani A Teotonio Rute R Smith April-Louise AL Bomanji Jamshed J Dickson John J Diehl Beate B Duncan John S JS Nachev Parashkev P
Brain : a journal of neurology 20200301 3
In theory the most powerful technique for functional localization in cognitive neuroscience, lesion-deficit mapping is in practice distorted by unmodelled network disconnections and strong 'parasitic' dependencies between collaterally damaged ischaemic areas. High-dimensional multivariate modelling can overcome these defects, but only at the cost of commonly impracticable data scales. Here we develop lesion-deficit mapping with metabolic lesions-discrete areas of hypometabolism typically seen on ...[more]
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