Ontology highlight
ABSTRACT:
SUBMITTER: Dupont WD
PROVIDER: S-EPMC7089954 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nature communications 20200323 1
The 8q24 genomic locus is tied to the origin of numerous cancers. We investigate its contribution to hereditary prostate cancer (HPC) in independent study populations of the Nashville Familial Prostate Cancer Study and International Consortium for Prostate Cancer Genetics (combined: 2,836 HPC cases, 2,206 controls of European ancestry). Here we report 433 variants concordantly associated with HPC in both study populations, accounting for 9% of heritability and modifying age of diagnosis as well ...[more]