Ontology highlight
ABSTRACT:
SUBMITTER: Shrivastava AN
PROVIDER: S-EPMC7091477 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Shrivastava Amulya Nidhi AN Bousset Luc L Renner Marianne M Redeker Virginie V Savistchenko Jimmy J Triller Antoine A Melki Ronald R
Biophysical journal 20200128 6
The aggregation of the protein α-synuclein (α-Syn) leads to different synucleinopathies. We recently showed that structurally distinct fibrillar α-Syn polymorphs trigger either Parkinson's disease or multiple system atrophy hallmarks in vivo. Here, we establish a structural-molecular basis for these observations. We show that distinct fibrillar α-Syn polymorphs bind to and cluster differentially at the plasma membrane in both primary neuronal cultures and organotypic hippocampal slice cultures f ...[more]