Dataset Information

Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials.

ABSTRACT:

Objectives

To outline the challenges and provide practical recommendations for recruiting inactive, statin-free older adults to facilitate feasible study designs. Data was obtained from a double-blind randomised-controlled clinical trial investigating the effects of acipimox versus placebo on muscle function and metabolism in older (65-75 years), inactive, statin-free males. The initial recruitment target was 20 volunteers within 12 months (November 2016-November 2017).

Results

Recruitment occurred via the Exeter 10,000 database containing 236 'eligible' males, a Facebook campaign reaching >?8000 ??65 years old males, 400 directly-addressed letters to ??66 year old males, >?1500 flyers distributed within the community, >?40 emails to local community groups, 4 recruitment talks, 2 magazine adverts and 1 radio advert. Widespread recruitment efforts reaching >?120,000 people led to the recruitment of 20 volunteers (18 completed the clinical trial) within a 25-month timeframe, highlighting the challenge of the timely recruitment of inactive, statin-free older adults for clinical trials. We recommend recruitment for future clinical trials should take a multi-pronged approach from the outset, prioritising the use of volunteer databases, Facebook campaigns and delivering recruitment talks.

SUBMITTER: Deane CS

PROVIDER: S-EPMC7092412 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Publications

Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials.

Deane Colleen S CS Phillips Bethan E BE Smith Kenneth K Steele Anna M AM Libretto Tina T Statton Sarah A SA Atherton Philip J PJ Etheridge Timothy T

BMC research notes 20200324 1

<h4>Objectives</h4>To outline the challenges and provide practical recommendations for recruiting inactive, statin-free older adults to facilitate feasible study designs. Data was obtained from a double-blind randomised-controlled clinical trial investigating the effects of acipimox versus placebo on muscle function and metabolism in older (65-75 years), inactive, statin-free males. The initial recruitment target was 20 volunteers within 12 months (November 2016-November 2017).<h4>Results</h4>Re ...[more]

PMID: 32209122

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Dataset Information

Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials.

Objectives

Results

Publications

Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials.

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