Neuroimaging and Bayley-III correlates of early hand function in extremely preterm children.

ABSTRACT:

Objective(s)

Investigate associations between 18 and 22-month corrected age hand function, adverse findings on serial cranial ultrasound (CUS) and near-term brain MRI (ntMRI), and Bayley-III scores in extremely preterm (EPT) toddlers.

Study design

Cohort analysis of Neonatal Research Network SUPPORT NEURO data. Associations between brain abnormalities, hand function, and Bayley-III scores were examined using chi-square and generalized linear mixed effect model analyses.

Results

A total of 433 children were included. Sixteen percent had hand function deficits; these were associated with late CUS (p < 0.001) abnormalities, white matter abnormality (WMA) on ntMRI (p < 0.001), and Bayley-III scores. Six percent had CP. Fourteen percent of children without and 50% of those

SUBMITTER: Duncan AF 

PROVIDER: S-EPMC7092795 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature