The nucleocapsid protein of SARS-associated coronavirus inhibits B23 phosphorylation.
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ABSTRACT:
SUBMITTER: Zeng Y
PROVIDER: S-EPMC7092856 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
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The nucleocapsid protein of SARS-associated coronavirus inhibits B23 phosphorylation.
Zeng Yingchun Y Ye Linbai L Zhu Shengli S Zheng Hong H Zhao Peng P Cai Weijia W Su Liya L She Yinglong Y Wu Zhenghui Z
Biochemical and biophysical research communications 20080201 2
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is responsible for SARS infection. Nucleocapsid (N) protein of SARS-CoV encapsidates the viral RNA and plays an important role in virus particle assembly and release. In this study, the N protein of SARS-CoV was found to associate with B23, a phosphoprotein in nucleolus, in vitro and in vivo. Mapping studies localized the critical N sequences for this interaction to amino acid residues 175-210, which included a serine/arginine ( ...[more]
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